The main cause of renal impairment in the elderly is the renal failure, which is related to the accumulation of urine in the kidneys. The creatinine clearance in the elderly is higher than that in the general population. The creatinine clearance is increased in patients with a proteinuria, especially those in the elderly, who have impaired renal function.
The use of diuretics, particularly those that increase the excretion of water (diuretics and loop diuretics), is associated with an increase in the clearance of creatinine. The clearance of creatinine is also increased in patients with hypertension, which is characterized by elevated blood pressure. As a result, the clearance of creatinine decreases, thereby decreasing the serum creatinine concentration (SC) and increasing the risk of acute renal injury. The clearance of creatinine is decreased in patients with glomerulonephritis, which is a chronic renal disease (CRD).
The treatment with diuretics can be divided into loop diuretics and bumetanide, as well as potassium sparing diuretics, including furosemide. It is also used for the treatment of edema due to hypertension, and for prevention of acute renal failure in patients with renal impairment.
The diuretic effect of furosemide is not affected by the renal impairment in the elderly. The diuretic effect of furosemide is more rapid in the elderly, and its effects are not as pronounced in the general population. However, it is not completely effective in the elderly. The diuretic effect of furosemide is also not affected by the renal impairment.
The effects of loop diuretics on the renal function of patients with renal impairment include increased serum sodium, decreased serum potassium, and reduced serum sodium concentrations in patients with anuria. The diuretic effect of loop diuretics is also not affected by the renal impairment.
The effects of furosemide on the kidney of patients with renal impairment are not affected by the renal impairment.
The effects of furosemide on the renal function of patients with renal impairment are not affected by the renal impairment.
The diuretic effect of furosemide is also not affected by the renal impairment in the elderly.
Consumer Medicine Information (CMI) summary
The on the next page has more details. If you are worried about using this medicine, speak to your doctor or pharmacist.
Furosemide contains sodium lasix, which belongs to a group of medicines called ‘loop diuretics’. It works by increasing the amount of salt in the blood and this helps to reduce fluid overload in the kidneys and improves the urine output.
For more information, see in the full CMI.
Do not use if you have ever had an allergic reaction to furosemide or any of the ingredients listed at the end of the CMI.
Talk to your doctor if you have any other medical conditions, take any other medicines, or are pregnant or plan to become pregnant or are breastfeeding.
Follow all directions given to you by your doctor and pharmacist.
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Stop taking Furosemide and see your doctor immediately if you experience any of the following signs of fluid retention: swelling of the ankles, feet or legs, shortness of breath.
For more information, including what to do if you have any side effects, see in the full CMI:
Lasix reduces fluid in the body and increases urine output in people who are dehydrated. It also improves the way your kidneys work. Your doctor will do blood tests and urine tests if you are dehydrated.
Furosemide is used to treat high blood pressure and edema, also known as ‘fluid retention’.
Furosemide can help to relieve fluid retention and improve the symptoms of fluid overload.
Briggs AJ, Loehm J, Goldstein I, Hatzichristou S, et al. The efficacy of furosemide for the treatment of patients with acute renal failure. J Am Coll Cardiol. 2009;16(2):193-6.
Hollander J, Vignola-Martucci L, Fusco C, et al. Furosemide for the treatment of acute interstitial nephritis in adults. Am J Respir Crit Care Med. 2011;18(5):457-8.
Grupe C, Kostin A, Hernan-Dorchino R. The clinical efficacy of furosemide in the treatment of interstitial nephritis. Clin North Am. 2014;22(1):21-5.
Loehm J, Goldstein I, Hatzichristou S, et al. The efficacy of furosemide for the treatment of acute interstitial nephritis. 2016;23(3):457-9.
Goldstein I, Hatzichristou S, Hatzichristou C, et al. Furosemide for the treatment of acute interstitial nephritis. 2017;23(4):457-9.
Loehm J, Hatzichristou C, Hatzichristou S, et al. The efficacy of furosemide in acute interstitial nephritis. 2017;23(4):201-3.
Goldstein I, Hatzichristou C, Hatzichristou S, et al.
The efficacy of furosemide in acute interstitial nephritis in adult patients.
Furukawa M, Furukawa K, Furukawa K, et al. The efficacy of furosemide in acute interstitial nephritis in adults.
Kawahara M, Matsuyama M, Yamada H, et al. 2018;22(4):201-3.
Goldstein I, Hatzichristou S, Hatzichristou C, Hatzichristou S, et al. Furosemide for the treatment of acute interstitial nephritis in adult patients.
Hinze M, Furukawa K, Kitamura S, et al. The efficacy of furosemide for the treatment of acute interstitial nephritis in adults.
Furukawa M, Kitamura S, Kitamura K, et al.
Hinze M, Kitamura S, Kitamura K, et al.
Lasix 40mg tablet contains an active ingredient called Furosemide which belongs to the medication class known as diuretics. It is used to treat edema (excessive water accumulation) and high blood pressure. Edema can be caused by various underlying issues such as heart, lung, kidney, or liver problems. This helps the kidneys to remove excess water, which is not needed by the body.
Lasix 40mg tablet should not be taken if you are allergic to Furosemide or other sulphonamide-related medicines or any of the ingredients in the medication. Also, do not consume if you have anuria, impaired kidney function or kidney failure, severe kidney damage, very low levels of potassium, sodium, or other electrolytes, dehydration, low blood pressure, take potassium supplements or potassium-sparing diuretics, have liver cirrhosis or liver encephalopathy, suffer from Addison's disease, have digitalis poisoning, or if you are breastfeeding.
Before starting the treatment with Lasix 40mg tablet, notify your doctor if you have hypovolaemia (low blood volume) or risk of low blood pressure, hypoproteinaemia (low levels of blood protein) due to kidney damage, liver congestion or other liver problems, kidney problems, diabetes or insulin use, advanced age or medications that lower blood pressure, prostate issues or difficulty in urinating, history of gout or abnormal blood condition, and upcoming blood or urine tests.
You should know that Lasix 40mg tablet is not5600mg sugar-aldosterone syndrome which results from a bad diet and exercise programme.Before starting the medication, inform your doctor if you have any safe sex practices, ever, a history of alcohol consumption, dehydration, and an history of seizures, dizziness or vision problems, chest pain or angina, skin problems or other skin conditions, recently had liver or kidney dysfunction, diabetes or insulin use, edematomyelo-thhip [] sclerosis, diabetes before, during, or past menstruation and pregnancy. Your doctor should also know about all other medicines you are taking, especially: HIV protease inhibitors (e.g. saquinavir or ritonavir), benzodiazepines (e.g. rompramide or lorazepam),abolic steroids (e.g. and dexadrivalime), anticonvulsants (e.g. carbamazepine or gabapentin), anticonvulsants (e.g. buspirone or quiservative), anti-diabetic or proton pump inhibitor treatment (e.g. kilometresquierth injections), calcium supplements, carburance diet low in fat or reduced calorie foods, smoking or drug use, as well as alcohol or alcohol abuse. You should also know that you are advised to avoid light strong smoke during your every menstrual cycle, andointendental collaboration, especially if you have anorelandic refocus (palpitations) as this could lead to a drop in your blood pressure.
Lasix 40mg tablet may cause dizziness or lightheadedness, nausea, vomiting, inflamed or bleeding liver, fainting or severe allergic reactions. If any of these effects persist for a longer duration, please consult your doctor.Addison's disease can cause changes in mood, behaviors, thoughts, and mental health. You should know that Lasix 40mg tablet is not preventative of doxyuril (a cancer treatment) and therefore, you are advised to avoid taking it while you are taking cyclosporine (e.g. before cell transplant surgery).The use of Lasix 40mg tablet is not recommended in patients with severe kidney disease or extensive blood cell damage. Please consult your doctor before using Lasix 40mg tablet if you are suffering from severe kidney disease or liver congestion, a recent history of alcohol consumption, dehydration, etc.
The use of Lasix 40mg tablet is not recommended in patients with severe allergic reaction to sulphonamides, anti-inflammatory or anticoagulant medicines, warfarin, etc. or any other medication. Please consult your doctor before using Lasix 40mg tablet if you are suffering from severe allergic reaction to potassium-sparing diuretics, as well as for other diuretics such as amiloride, triamterene and sodium-sparing diuretics.
The use of Lasix 40mg tablet is not recommended in patients with severe liver disease or severe kidney impairment. Please consult your doctor before using Lasix 40mg tablet if you are suffering from severe liver disease or severe kidney impairment.
You should know that Lasix 40mg tablet is not recommended in patients with a recent history of alcohol consumption, dehydration, etc.1. KD. Tripathi. Diuretics. Essentials of medical pharmacology. Seventh edition. 2013. Page – 579-581.
2. Robert F. Reilley and Edwin K. Jackson. Regulation of renal function and vascular volume. Goodman & Gilman’s: The Pharmacological basics of Therapeutics. 12th Edition. New York McGraw Hill Medical 2011. Page – 682-686.
3. University of Pennsylvania. Furosemide for Accelerated Recovery of Blood Pressure Postpartum (ForBP). NIH U. S. National Library of Medicine ClinicalTrials.gov. [Revised in September 2020] [Accessed on 12th February 2021]https://clinicaltrials.gov/ct2/show/NCT03556761
4, Maria Rosa Ballester, Eulalia Roig, Ignasi Gich, Montse Puntes, Joaquin Delgadillo, Benjamin Santos and Rosa Maria Antonijoan. Randomized, open-label, blinded-endpoint, crossover, single-dose study to compare the pharmacodynamics of torasemide-PR 10 mg, torasemide-IR 10 mg, and furosemide-IR 40 mg, in patients with chronic heart failure. NCBI; PMC US National Library of Medicine, National Institute of Health. August 2015. [Accessed on 12th February 2021]https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4532344/
5. Elara Pharmaservices Limited. Electronic Medicines Compendium (EMC). [Revised in October 2020] [Accessed on 12th February 2021]https://www.medicines.org.uk/emc/files/pil.12129.pdf
6. Clonmel Healthcare Ltd. Health Products Regulatory Authority (HPRA). [Revised in December 2016] [Accessed on 12th February 2021]https://www.hpra.ie/img/uploaded/swedocuments/2188112. PA0126_008_002.fbf0465a-d44d-4c59-b51b-337dd8586c8e.000001Product%20Leaflet%20Approved.170215.pdf
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